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<title>Entactin</title>

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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Entactin</span></h1>

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<th colspan="3" style="background:#90EE90; color:#202122;">Entactin

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<td colspan="3" class="hintergrundfarbe1" style="text-align:center; font-size:smaller; font-weight:bold;"><a href="B%C3%A4ndermodell_(Proteine)" title="Bändermodell (Proteine)">Bändermodell</a> von Entactin, nach <a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1GL4">1GL4</a>

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<td>Andere Namen

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<ul><li>Nidogen</li>

<li>Nidogen-1 (NID-1)</li></ul>

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<p>Vorhandene Strukturdaten: <a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1NDX">1NDX</a>

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<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins

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<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>

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<td colspan="2" style="text-align:center;">1.247 <a href="Aminos%C3%A4uren" title="Aminosäuren">Aminosäuren</a>, 136.377 <a href="Atomare_Masseneinheit" title="Atomare Masseneinheit">Da</a>

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<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner

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<td><a href="Human_Genome_Organisation" title="Human Genome Organisation">Gen-Namen</a>

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<td colspan="2" class="" style="text-align:center;"><i><a rel="nofollow" class="external text" href="https://www.genenames.org/tools/search/#!/all?query=7821">NID1</a></i>, NID

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<td>Externe IDs

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<ul><li><a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=NID1">NID1</a></li>

<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P14543">P14543</a></li>

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<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen

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<td style="background:#C3FDB8; color:#202122;">Homologie-Familie

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<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P14543">Hovergen</a>

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<td style="background:#C3FDB8; color:#202122;">Übergeordnetes <a href="Taxon" title="Taxon">Taxon</a>

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<td colspan="2" style="text-align:center;"><a href="Eumetazoa" class="mw-redirect" title="Eumetazoa">Eumetazoa</a>

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<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a>

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<td style="background:#C3FDB8; color:#202122; text-align:center;">Mensch

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<td style="background:#C3FDB8; color:#202122; text-align:center;">Hausmaus

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<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>

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<td style="background:#C3FDB8; color:#202122;"><a href="Ensembl" title="Ensembl">Ensembl</a>

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<td><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000005397;db=core">ENSMUSG00000005397</a></small></small></span>

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<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>

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<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (mRNA)

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<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (Protein)

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<td style="background:#C3FDB8; color:#202122;"><a href="Genlocus" title="Genlocus">Genlocus</a>

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<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche

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</p><p><b>Entactin</b> oder <b>Nidogen</b> ist ein <a href="Glykoprotein" class="mw-redirect" title="Glykoprotein">Glykoprotein</a>, das in der <a href="Basalmembran" title="Basalmembran">Basalmembran</a> von Zellen exprimiert wird und aus drei globulären Domänen (G1, G2 und G3) besteht. Die G3-Domäne kann an das Glykoprotein <a href="Laminin" class="mw-redirect" title="Laminin">Laminin</a> binden, die G2 Domäne an Zellen und Kollagen IV. So ist Entactin als Teil der extrazellulären Matrix netzwerkbildend und spielt bei Zellinteraktionen eine Rolle.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>

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<div class="mw-heading mw-heading2"><h2 id="Literatur">Literatur</h2></div>

<ul><li>Albert E. Chung, Li-Jin Dong, Chuanyue Wu, Marian E. Durkin: <cite style="font-style:italic">Biological functions of entactin</cite>. In: <cite style="font-style:italic">Kidney International</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>43</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, 1993, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>13–19</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1038/ki.1993.4">10.1038/ki.1993.4</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Entactin&rft.atitle=Biological+functions+of+entactin&rft.au=Albert+E.+Chung%2C+Li-Jin+Dong%2C+Chuanyue+Wu%2C+...&rft.date=1993&rft.doi=10.1038%2Fki.1993.4&rft.genre=journal&rft.issue=1&rft.jtitle=Kidney+International&rft.pages=13-19&rft.volume=43" style="display:none"> </span></li>

<li>D. Reinhardt, K. Mann, R. Nischt, J. W. Fox, M. L. Chu, T. Krieg, R. Timpl: <cite style="font-style:italic">Mapping of nidogen binding sites for collagen type IV, heparan sulfate proteoglycan, and zinc</cite>. In: <cite style="font-style:italic">Journal of Biological Chemistry</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>268</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>15</span>, 1993, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>10881–10887</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/S0021-9258%2818%2982067-1">10.1016/S0021-9258(18)82067-1</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Entactin&rft.atitle=Mapping+of+nidogen+binding+sites+for+collagen+type+IV%2C+heparan+sulfate+proteoglycan%2C+and+zinc&rft.au=D.+Reinhardt%2C+K.+Mann%2C+R.+Nischt%2C+...&rft.date=1993&rft.doi=10.1016%2FS0021-9258%2818%2982067-1&rft.genre=journal&rft.issue=15&rft.jtitle=Journal+of+Biological+Chemistry&rft.pages=10881-10887&rft.volume=268" style="display:none"> </span></li>

<li>Li-Jin Dong, Jyh-Cheng Hsieh, Albert E. Chung: <cite style="font-style:italic">Two Distinct Cell Attachment Sites in Entactin Are Revealed by Amino Acid Substitutions and Deletion of the RGD Sequence in the Cysteine-rich Epidermal Growth Factor Repeat 2 (∗)</cite>. In: <cite style="font-style:italic">Journal of Biological Chemistry</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>270</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>26</span>, 1995, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>15838–15843</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1074/jbc.270.26.15838">10.1074/jbc.270.26.15838</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Entactin&rft.atitle=Two+Distinct+Cell+Attachment+Sites+in+Entactin+Are+Revealed+by+Amino+Acid+Substitutions+and+Deletion+of+the+RGD+Sequence+in+the+Cysteine-rich+Epidermal+Growth+Factor+Repeat+2+%28%E2%88%97%29&rft.au=Li-Jin+Dong%2C+Jyh-Cheng+Hsieh%2C+Albert+E.+Chung&rft.date=1995&rft.doi=10.1074%2Fjbc.270.26.15838&rft.genre=journal&rft.issue=26&rft.jtitle=Journal+of+Biological+Chemistry&rft.pages=15838-15843&rft.volume=270" style="display:none"> </span></li>

<li>P. D. Yurchenco, J. C. Schittny: <cite style="font-style:italic">Molecular architecture of basement membranes.</cite> In: <cite style="font-style:italic">FASEB J.</cite> 6. Auflage. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>4</span>, 1990, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>1577–90</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1096/fasebj.4.6.2180767">10.1096/fasebj.4.6.2180767</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/2180767?dopt=Abstract">PMID 2180767</a> (<a rel="nofollow" class="external text" href="https://semanticscholar.org/paper/3e5fc067ca58654404cae4d6c3f66ffd4c29c7a7">semanticscholar.org</a>).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rfr_id=info:sid/de.wikipedia.org:Entactin&rft.atitle=Molecular+architecture+of+basement+membranes.&rft.au=P.+D.+Yurchenco%2C+J.+C.+Schittny&rft.btitle=FASEB+J.&rft.date=1990&rft.doi=10.1096%2Ffasebj.4.6.2180767&rft.edition=6&rft.genre=book&rft.pages=1577-90&rft.pmid=2180767&rft.volume=4" style="display:none"> </span></li></ul>

<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>

<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text">A. E. Chung, M. E. Durkin: <cite style="font-style:italic">Entactin: structure and function</cite>. In: <cite style="font-style:italic">American Journal of Respiratory Cell and Molecular Biology</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>3</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, 1990, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>275–282</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1165/ajrcmb%2F3.4.275">10.1165/ajrcmb/3.4.275</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/2119632?dopt=Abstract">PMID 2119632</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Entactin&rft.atitle=Entactin%3A+structure+and+function&rft.au=A.+E.+Chung%2C+M.+E.+Durkin&rft.date=1990&rft.doi=10.1165%2Fajrcmb%2F3.4.275&rft.genre=journal&rft.issue=4&rft.jtitle=American+Journal+of+Respiratory+Cell+and+Molecular+Biology&rft.pages=275-282&rft.pmid=2119632&rft.volume=3" style="display:none"> </span></span>

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